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Several possible pathophysiological mechanisms could explain how obstructive sleep apnea can cause or worsen depression. Sleep apnea can cause depression introduction. Pin By Dr Douglas Hauck On Sleep Apnea Sleep Apnea What Causes A knowledge of the intellectual and emotional impact of sleep apnea may be important in making a correct differential diagnosis. Sleep apnea can cause depression . Though some studies suggest a mutual relationship the relationship remains unclear. The condition raises. The cause of depression is not known but it can be effectively controlled with treatment. Patients with sleep apnea suffer a lack of oxygen which may cause changes to the brain resulting in depression. Similarly sleep apnea may cause inflammation in the body and affect neurotransmitter activity which could then contribute to symptoms of depression. One theory is that the lack of oxygen hypoxia that occurs with sleep apnea may cause problems in the body and brain that lead to depres...